Manufacturing Process and Introduction of Microlens Array and Physical Lifelike Brain Simulator
Media Coverage: Innovative 3D Brain Surgery Training Simulation System (By Formosa TV News Network)
To train neurosurgery interns and increase their confidence and surgical skills, we employed 3D printing, mold design, and casting technology to develop medical simulators. The simulators allow students to adjust the angle of the head based on the location of the angioma (brain tumor), perform a craniotomy, move the soft tissue of the brain aside using forceps, locate the angioma (brain tumor), and clip the angioma (remove the brain tumor) using medical instruments, and complete the entire training while artificial blood is flowing through the simulator.
To train neurosurgery interns and increase their confidence and surgical skills, we employed 3D printing, mold design, and casting technology to develop medical simulators. The simulators allow students to adjust the angle of the head based on the location of the angioma (brain tumor), perform a craniotomy, move the soft tissue of the brain aside using forceps, locate the angioma (brain tumor), and clip the angioma (remove the brain tumor) using medical instruments, and complete the entire training while artificial blood is flowing through the simulator.
Intro to MINI/MICRO/Manufacturing Lab.
Rapidly and Simultaneously Quantifying Multiple Biomarkers of Tyrosine Hydroxylase Deficiency by Using Paper Microfluidic Devices and Smartphone-Based Analysis System
(With Prof. Yi-Chun Yeh from Chemistry Dept. of NTNU)
Tyrosine hydroxylase (TH) is a critical enzyme and involved in the conversion of tyrosine to L-DOPA in the human body. TH deficiency is a rare autosomal recessive disorder which results in cerebral catecholamine deficiency and causes symptoms of depression, movement disorders, and impaired development. L-DOPA is the common precursor of catecholamine neurotransmitters, therefore how to rapidly and precisely determine the ratio of L-DOPA to tyrosine in the bio-matrix is important to the clinical diagnosis of disorder. To response the demand, a low-cost, user-friendly, and on-site detection system is developed herein, which includes a wax-printing paper microfluidics as reaction platform, surface modification with sodium periodate for improving detection performance, an additive manufactured enclosed case for maintaining identical detection environment, and an IOS APP to drive smartphone’s imaging to facilitate high-throughput quantification of multiple biomarkers simultaneously.
(With Prof. Yi-Chun Yeh from Chemistry Dept. of NTNU)
Tyrosine hydroxylase (TH) is a critical enzyme and involved in the conversion of tyrosine to L-DOPA in the human body. TH deficiency is a rare autosomal recessive disorder which results in cerebral catecholamine deficiency and causes symptoms of depression, movement disorders, and impaired development. L-DOPA is the common precursor of catecholamine neurotransmitters, therefore how to rapidly and precisely determine the ratio of L-DOPA to tyrosine in the bio-matrix is important to the clinical diagnosis of disorder. To response the demand, a low-cost, user-friendly, and on-site detection system is developed herein, which includes a wax-printing paper microfluidics as reaction platform, surface modification with sodium periodate for improving detection performance, an additive manufactured enclosed case for maintaining identical detection environment, and an IOS APP to drive smartphone’s imaging to facilitate high-throughput quantification of multiple biomarkers simultaneously.
New Psychoactive Substance (NPS) Detection in Urine via State-of-the-art MS-Raman Spectroscopy
(With Prof. Pai-Shan Chen from Toxicology Institute of NTU, Prof. Yi-Hsin Liu from Chemistry Dept. of NTNU, and Prof. Lian-Yu Chen from Kunming Prevention and Control Center of Taipei City Hospital)
The use of new psychoactive substance (NPS) is an increasingly public health threat worldwide. In addition to its health burden, it is also related to crime and many other social problems. Our team used the dual confirmation technology of "mass spectrometry and Raman", combined with the "chip microfluidic system" built by 3D printing, to be able to analyze the emerging psychoactive substances in complex urine simply and quickly.
(With Prof. Pai-Shan Chen from Toxicology Institute of NTU, Prof. Yi-Hsin Liu from Chemistry Dept. of NTNU, and Prof. Lian-Yu Chen from Kunming Prevention and Control Center of Taipei City Hospital)
The use of new psychoactive substance (NPS) is an increasingly public health threat worldwide. In addition to its health burden, it is also related to crime and many other social problems. Our team used the dual confirmation technology of "mass spectrometry and Raman", combined with the "chip microfluidic system" built by 3D printing, to be able to analyze the emerging psychoactive substances in complex urine simply and quickly.
Using Additive Manufacturing and Molding Techniques to Create Lifelike Cerebral Cancer Simulator for Training Neurosurgeons
(With Prof. Wei-Hsiu Liu from Tri-Service General Hospital and National Defense Medical Center)
(With Prof. Wei-Hsiu Liu from Tri-Service General Hospital and National Defense Medical Center)
Engineering Additive Manufacturing and Molding Techniques to Create Lifelike Willis’ Circle Simulators with Aneurysms for Training Neurosurgeons
(With Prof. Wei-Hsiu Liu from Tri-Service General Hospital and National Defense Medical Center)
Neurosurgeons require considerable expertise and practical experience in dealing with the critical situations commonly encountered during difficult surgeries; however, neurosurgical trainees seldom have the opportunity to develop these skills in the operating room. Therefore, physical simulators are used to give trainees the experience they require. In this study, we created a physical simulator to assist in training neurosurgeons in aneurysm clipping and the handling of emergency situations during surgery. Our combination of additive manufacturing with molding technology, elastic material casting, and ultrasonication-assisted dissolution made it possible to create a simulator that realistically mimics the brain stem, soft brain lobes, cerebral arteries, and a hollow transparent Circle of Willis. One neurosurgical trainee reported that the physical simulator helped to elucidate the overall process of aneurysm clipping and provided a realistic impression of the tactile feelings involved in this delicate operation.
(With Prof. Wei-Hsiu Liu from Tri-Service General Hospital and National Defense Medical Center)
Neurosurgeons require considerable expertise and practical experience in dealing with the critical situations commonly encountered during difficult surgeries; however, neurosurgical trainees seldom have the opportunity to develop these skills in the operating room. Therefore, physical simulators are used to give trainees the experience they require. In this study, we created a physical simulator to assist in training neurosurgeons in aneurysm clipping and the handling of emergency situations during surgery. Our combination of additive manufacturing with molding technology, elastic material casting, and ultrasonication-assisted dissolution made it possible to create a simulator that realistically mimics the brain stem, soft brain lobes, cerebral arteries, and a hollow transparent Circle of Willis. One neurosurgical trainee reported that the physical simulator helped to elucidate the overall process of aneurysm clipping and provided a realistic impression of the tactile feelings involved in this delicate operation.